● Students supervision
- PhD students
Linda Tomy, Novel neural mass models integrating neuroplasticity, 2022-25
Alihan Kayabas, Brain models for tDCS, 2022-25
Dauly Gautier, Microelectrode design for HFO recording, 2020-23
Arrais M, Multi-site therapeutic stimulation : dynamic models and application to epileptic seizures, 2017-20
Rizkallah J, EEG source connectivity in disorders of consciousness, 2016-19
Carvallo A, Invasive neuromodulation in epilepsy, 2015-18
Denoyer Y (MD), TDCS in epilepsy, 2015-18
Kuchenbuch M (MD), Migrating Partial Seizures in Infancy, 2015-18
Shamas M, Virtual Epileptic Brain, 2014-17
Mheich A, Graph matching in neural coding, 2013-16
Dietrich Y, EEG, qMRI and MALDI in epileptogenesis, 2013-16
Mina F, Neurostimulations & epilespy: insights from computational models, 2010-2013
Huneau C, A combined theoretical/experimental study of depth-EEG signals in temporal lobe epilepsy, 2008-2011
Demont S, Reconstruction of LFPs from detailed neuron models, 2006-2009
Cosandier-Rimélé D, Fusion of models for interpretation of scalp and depth EEG signals, 2003-2007
Ansari K, Characterization of interdependencies between EEG signals: application to epilepsy, 2001-2005
Bourien J, Analysis and classification of depth EEG signals in temporal and frontal epilepsies, 2000-2003
Bouillon Y, Computer-supported collaborative work: practical aspects in signal and image processing, 1998-2001
Shamsollahi M, Time-frequency analysis of depth-EEG signals, 1994-1997
- Post-doc fellows
Peuvrier M, Epileptic spike detection in EEG recordings, 2023-25
Al Harrach M, Model-guided design of micro-electrodes for HFO recording, 2019-23
Zahran S, Computational modeling of EEG -tDCS for consciousness studies, 2019-21
Koksal E, Bifurcation analysis in neural mass models, 2018-2023
Yochum M, Therapeutic neurostimulation in epilepsy, 2016-2018
Bensaid S, Computational modeling of EEG for consciousness studies, 2016-19
Hassan M, EEG source connectivity, 2012-2017
Jrad N, Detection of HFOs, 2013-2015
Birot G., Automatic detection of fast ripples, 2012-13
Blanchard S, Models of neuro-vascular coupling, 2008-2010
Molaee-ardekani B, Effects of electrical currents on neuronal networks, 2008-2010
Labyt, E, Computational modeling of entorhinal cortex, 2005-2006
Maby, E, Analysis of evoked potentials of the brain stem, 2003-2004
● Main grants
- NIH, USA. R01 grant on neurostimulation in Epilepsy (NS092760-01A1). 2016-21
- European Project “HIVE”: “Hyper-interaction viability experiments” (FP7, FET Call). Leader of Work Package 1 « Biophysical models of brain stimulation »). 2008-2012 (http://hive-eu.org/)
- ANR-DGOS. 2014-18
- Labex CominLabs. 2012-17
- Regional Council of Brittany. 2006-2009, 2010-2013
- French Foundation for Research on Epilepsy. 2004-2006
- French Research Ministry - ACI “Integrative and computational neurosciences” in collaboration with Inserm U751. 2003 – 2006
- French Research Ministry - ACI “Technologies for Health”. 2000 – 2003
● Editorship
- Associate Editor IEEE Trans. Biomed. Eng. (2011-13)
- Associate Editor Neurophysiologie Clinique/Clinical Neurophysiology (2011-)
- Member Editorial board of Brain Topography (2007-)
- Guest Editor Special Issue of J Clin. Neurophysiol. on Neurocomputational Models in the Study of Epileptic Phenomena (2005)
- Permanent member of the technical committee on Neural Engineering (TCNE) - IEEE Conference on Eng. in Med. and Biol. (EMBC) (2005-)
● Ad hoc Reviewer
Biological Cybernetics, Brain, Clinical Neurophysiology, Epilepsia, IEEE Transactions on Biomedical Engineering, Journal of Neuroscience Methods, NeuroImage, Journal of the Royal Society Interface, PRE, eNeuro
● Invited conferences and seminars
Montreal (MNI, 1998), University of Houston (1998), Collège de France (1999), Ministry of Research (2002), Amsterdam (SEIN, 2002), Milan (Neurological Institute C. Besta, 2004), Université de Bonn (Epilepsy Unit, 2005), Bernstein Center for Computational Neuroscience, Freiburg (2006), Réseau National des Systèmes Complexes, Paris (2007, http://webcast.in2p3.fr/RNSC/index.php?video=wendling.ram), Encontros da Arrabida, «Roads to Complexity – Life Sciences», Lisbon (2007), International Workshop on Epileptic Seizure Prediction, Freiburg (2007), Brainmodes Meeting Amsterdam (2008), Fukuoka, Japan (International Workshop on Advanced Epilepsy Treatment, CADET 2009, http://www.brain.kyutech.ac.jp/~cadet/CADET2009/invited_speakers.html), Banff, Canada (The Keith Worsley workshop on Computational Modeling of Brain Dynamics: from stochastic models to Neuroimages, 2009, http://www.birs.ca/birspages.php?task=eventvideos&event_id=09w5092), Dynamics of the Disease workshop, Manchester (2011), High Frequency Oscillations Meeting, Montreal (2011), International Workshop on Epileptic Seizure Prediction, Dresden (2011), European Congress on Epileptology (ECE), London (2012), Christian Albrechts University Kiel (2012), Institut de France (2012), Société de Mathématiques Appliquées et Industrielles, Paris (2012), Dartmouth-Hitchcock Medical Center, Dartmouth, USA (2012), Institut Polytechnique de Milan (2013), INMED (2014), ENS (Neural Theory Group, 2014), Univ-Montpellier (M2H, 2014), 3rd Int. Conf. on Neural Field Theory (ICNFT), Reading, UK (2014), Montreal Canada (2014), Beyruth, Libanon (2015), Antwerp, Belgium (2017), Cleveland Clinic, USA (2018), Washington (2018), HBP International Conference (2018).
● Patents: 8 - Book Chapters: 10
● Teaching
Every year, I give lectures for engineering students (TELECOM Bretagne, Ecole Centrale de Nantes, Ecole Nationale des Ponts et Chaussées) and for young clinicians (Neurophysiology and epileptology). The topic is “EEG signal processing and modeling”. The total amount is about 15 hours per year.
Birth date: 24/01/1967
Position:
2008 - : INSERM Research Director (equiv. full professor. DR2: 2008; DR1: 2017; DRCE: 2024).
1998 - 2008 : INSERM Research Scientist (“Chargé de recherche”)
1996 - 1998 : Assistant professor, University of Rennes 1
2012- : Head of the team SESAME: “Epileptogenic Systems: Signals and Models”, LTSI - Inserm U1099, Rennes, France
2004-2011: Head of the team EPIC: “Dynamics of neuronal systems in Epilepsy”, LTSI - Inserm U642, Rennes, France
● Education
- Accreditation to supervise research, University of Rennes 1, Rennes, France (2003)
Title: “Analysis and modeling of EEG signals. Contribution to the study of the pathophysiology of human partial epilepsies”
- Engineer diploma (Biomedical Eng.), University of Technology of Compiègne, Compiègne, France (1989)
● Research activity
Since 2004, I am leading a research team on the dynamics of neuronal systems in the context of epilepsy. I have been working in this field for almost 20 years in close collaboration with neurologists. My expertise relates to the analysis of brain signals and to the (patho)physiological modeling of neuronal systems. I have developed specific methods to analyze electrophysiological signals (scalp and intracerebral EEG, LFPs), recorded during interictal or ictal periods (among which the “epileptogenicity index”, Brain, 2008). I have also developed computational models of brain activity (at cellular, neural population and brain level, JNM 2015). Some of these models were specifically adapted to the cellular organization of brain structures predominantly involved in temporal lobe epilepsy (like the hippocampus and the entorhinal cortex, see http://www.scholarpedia.org/article/Models_of_epilepsy). They are used worldwide to interpret local field potentials recorded from the epileptic brain during interictal (spikes and fast ripples, Annals of Neurology 2012) and seizure periods. My intent is now to promote the combination of compuational and experiemental (in vivo & in vitro) approaches, both in a diagnostic and therapeutic prospective. To me, this approach can significantly improve our understanding of the mechanisms underlying the generation of epileptic events, both at chronic stage and during epileptogenesis (EJN 2012) and lead to novel therapeutic procedures, in particular based on electrical stimulation. I authored/co-authored about 150 papers in peer-reviewed journals and 4 patents. Journals can be divided in two categories according to their scope, either “methodological” (IEEE TBME, IEEE TITB, Annals Biomed. Eng., PTRSA) or “clinical” (Brain, Clin. Neurophysiol., J. Neurophysiol., J. Physiol.).
● Scientific review/evaluation of national research projects
2016-21 Member of the Scientific Evaluation Commission 4 “Neurosciences”, INSERM
2016-18 Member of Scientific Evaluation Committee “Technologies for health”, French Nat. Res. Agency
● Awards and honors
2012 Award of the French Academy of Science (“Prix Michel Monpetit”, for “outstanding
contribution to the processing and modeling of electrophysiological signals
2010-13 Awardee of an Inserm Contract for Translational Research
2009-12 Awardee of a CREATE (CREAtivity & Exploratory Topics, Region Bretagne)
research contract on diagnostic stimulation in epilepsy
1998 Young investigator award from Brittany Regional Council
1996 First award, 8th Congress of the French Society of Biomedical Engineering
1989 Scholarship Awardee (“Bourse d’excellence Lavoisier”), French Ministry
of Foreign Affairs
Copyright LTSI - Inserm - Université de Rennes 1 (all rights reserved)
Fabrice Wendling
"Epileptogenic Systems: Signals and Models"
Research director (DR1 Inserm)
LTSI, Inserm U1099, University of Rennes